A round-up of the day's news, sport and business stories, and a look at the morning's papers.

Sean Farrington and David Jones look at the impact of a 'Brexit' on business as the campaign is launched for a 'leave' vote in the EU referendum. Show more

Nicky Campbell and Rachel Burden with news and sport from the UK and around the world. Big-name interviews and topical debates - plus regular travel and weather updates. Show more

Your calls on the day's big story with Nicky Campbell.

A couple whose baby was adopted after they were wrongly accused of child abuse say their baby has been stolen from them. Show more

Eleanor Oldroyd is joined by Fran Kirby, Ally Hogg and Annie Vernon to discuss the week's sporting issues. Show more

Writer Abi Morgan talks to Simon about Suffragette. Plus the Box Office Top 10 and Mark's reviews of the week's new films, including Regression and Sicario. Show more

Labour accuses the government of being in denial about financial issues facing the NHS after health regulators warn the service is in its worst financial position for a generation. Show more

Caroline Barker presents build-up to England v Estonia in their Euro 2016 qualifier, plus the day's sports news.

Live international football commentary on England v Estonia in their Euro 2016 qualifier. Plus updates from New Zealand v Tonga in the Rugby World Cup.

Patients and health policy experts have their say on the financial crisis facing NHS trusts in England. Plus Michael O'Neill on Northern Ireland's Euro 2016 qualification. Show more

The US changes its tactics in Syria, abandoning its programme to train new rebel fighters. Attacks on homes for asylum seekers in Germany rise. And the World Football Phone-In. Show more