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BBC Inside Science: Predicting Long Covid, and the Global Toll of Antimicrobial Resistance

10/06/2021

Predicting Long Covid, and the Global Toll of Antimicrobial Resistance

BBC Radio 4 - BBC Inside Science, Predicting Long Covid, and the Global Toll of Antimicrobial Resistance

Promising results suggest new biomarkers could rate the risk of developing Long Covid.

Promising results suggest two blood markers could rate the risk of developing Long Covid, plus reports of how Antibiotic Microbial Resistance is already a serious global killer.

Prof Onur Boyman, Director of department of Immunology at University Hospital, Zurich, this week published a paper in the journal Nature Communications that presents a way of quantifying the risk of a Covid patient going on to develop Long Covid (or PACS as some call it) based on certain symptoms, but crucially also two key biomarkers in the blood. As he explains to Gaia, combining the levels in the blood of two key immunoglobulins (IgM and IgG3) with other pointers, first identified last year, allowed him and his team to make successful predictions as to the relative likelihood his sample group of patients might go on to still be exhibiting symptoms beyond four weeks after infection. Asthma is of particular interest to these researchers, partly because it can share this blood signal of Ig markers. Might it even also shed any light on things such as Chronic Fatigue Syndrome?

Dr Claire Steves, of Kings College London, whose previous work on symptom gathering Onur's team have built upon, agrees this is a promising bit of work, and also discusses some other potential clues to the Long Covid mystery.

But Covid of course is not the the only major cause of death in the world today. A major paper in the Lancet recently is one of the first deep estimates of the global health burden of Antibiotic Microbial Resistance. And it suggests that 1.25 million people died in the world in 2019 because many bacteria are evolving a resistance to our favourite antibiotics. As Prof Chris Murray, Director of the Institute for Health Metrics and Evaluation at the University of Washington who led the massive collaboration explains. The surprisingly huge number points to a massive and growing problem that political and health leaders around the world must address.

And finally, the genetics of fingerprints might be a bit better understood thanks to work published in Cell recently. Dr Denis Headon of the Roslyn Institute at the University of Edinburgh talks to Gaia about a huge survey he and colleagues have done looking at the hints certain genes can give as to the types of fingerprints you grow. The genes that seem to govern the general form of your prints are the ones that shape your limb development, rather than skin patterns as perhaps might be expected. And a pro-tip if you want to search the literature for more info on this: use the word "dermatoglyph" rather than the overused and progressively meaningless word "fingerprint".

Presented by Gaia Vince
Producer Alex Mansfield
Assistant Producer Emily Bird

Made in Association with The Open University.

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