Original version

BBC World Service East and Southern Africa Schedule

BBC World Service East and Southern Africa

Science in Action

Science In Action

Factual: Science & Nature

Factual: Science & Nature: Science & Technology

The BBC brings you all the week's science news.

BBC World Service Australasia

BBC World Service Online

BBC World Service schedule for American satellite radio and the Caribbean

BBC World Service Americas and the Caribbean

BBC World Service

BBC World Service South Asia

BBC World Service News Internet

BBC World Service Europe and the Middle East

BBC World Service West and Central Africa Schedule

BBC World Service West and Central Africa

BBC World Service East Asia

Science In Action: Your molecular machinery, now in 3D

Magazines & Reviews

Protein folding

22/07/2021 GMT

Your molecular machinery, now in 3D

BBC World Service - Science In Action, Your molecular machinery, now in 3D

DeepMind publishes 350,000 of the structures which make all living things tick.

DeepMind publishes 350,000 of the molecular structures which make all living things tick. Plus, Covid-19 vaccination strategy reimagined, and seismic sensitivities of elephants.

Back in November it was announced that an AI company called DeepMind had essentially cracked the problem of protein folding – that is they had managed to successfully predict the 3D structures of complex biochemical molecules by only knowing the 2D sequence of amino acids from which they are made.

They are not the only team to use machine learning to approach the vast amounts of data involved. But last week, they released the source code and methodology behind their so called AlphaFold2 tool. Today, they are publishing via a paper in the journal Nature, a simply huge database of predicted structures including most of the human proteome and 20 other model species such as yes, mice. The possibilities for any biochemists are very exciting. 

As DeepMind CEO Demis Hassabis tells Roland Pease, they partnered with the European Molecular Biology Laboratory to make over 350,000 protein predictions available to researchers around the world free of charge and open sourced. Dr Benjamin Perry of the Drugs for Neglected Diseases Initiative told us how it may help in the search for urgently needed drugs for difficult diseases such as Chagas disease. Prof John McGeehan of the Centre for Enzyme Innovation at Portsmouth University in the UK is on the search for enzymes that might be used to digest otherwise pollutant plastics. He received results (that would have taken years using more traditional methods) back from the AlphaFold team in just a couple of days.

Prof Julia Gog of Cambridge University is a biomathematician who has been modelling Covid epidemiology and behaviour. In a recent paper in Royal Society Open Science, she and colleagues wonder whether the vaccination strategy of jabbing the most vulnerable in a population first, rather than the most gregarious or mobile, is necessarily the optimal way to protect them. Should nations still at an early stage in vaccine rollout consider her model?

And did you know that elephants can hear things up to a kilometre away through their feet? And that sometimes they communicate by bellowing and rumbling such the ground shakes? Dr Beth Mortimer of Oxford University has been planting seismic detectors in savannah in Kenya to see if they can tap into the elephant messaging network, to possibly help conservationists track their movements.

Image: Protein folding
Credit: Nicolas_/iStock/Getty Images

Presenter: Roland Pease
Producers: Alex Mansfield and Samara Linton

Accessibility links

Programme Index

Science In Action

Your molecular machinery, now in 3D

Genres

Formats

Brand

BBC World Service East and Southern Africa

About BBC World Service