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Witness History: Recreating Down Syndrome in Mice

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Recreating Down Syndrome in Mice

08/12/2016 GMT

BBC World Service - Witness History, Recreating Down Syndrome in Mice

Scientist Elizabeth Fisher created a new strain of mouse to help understand Down Syndrome

By transplanting the human chromosome responsible for Down Syndrome into mice, scientist Elizabeth Fisher transformed our understanding of a disorder affecting millions.

In 2005 British scientist Elizabeth Fisher and a colleague successfully transplanted a human chromosome into a mouse for the first time. It transformed medical research into the genetic condition Down Syndrome that affects millions of people worldwide. Professor Fisher tells Louise Hidalgo about the challenges researchers faced and their thirteen-year struggle to create the first Down Syndrome mouse.

Photo: Science Photo Library

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